IgA Nephropathy.
نویسندگان
چکیده
IgA nephropathy (IgAN) is a leading cause of CKD and renal failure. Recent international collaborative efforts have led to important discoveries that have improved our understanding of some of the key steps involved in the immunopathogenesis of IgAN. Furthermore, establishment of multicenter networks has contributed to rigorous design and execution of clinical trials that have provided important insights regarding immunotherapy in IgAN. In this article, we review emerging developments in clinical and translational IgAN research and describe how these novel findings will influence future strategies to improve the outcome of patients with IgAN.
منابع مشابه
Clinical, Histopathological and Immunofluorescent Findings of IgA Nephropathy
Background: IgA nephropathy, a prevalent disease in Asia, is considered the main cause of end stage renal disease among primary glomerular disease. Objective: To determine the frequency of different clinical, histopathological and immunofluorescent characteristics of IgA nephropathy. Methods: Renal biopsies of 376 patients were received for immunofluorescent and for histopathological studies. B...
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During a 14-month period (Dec. 1990-Jan. 1992) , renal biopsies were performed on 105 patients with suspected glomerular disease. All specimens were processed for light microscopy (L.M) and immunoflourescence. Work-up revealed 21 patients to suffer a systemic glomerular disease and glomerular disease was found to be primery in 85 cases. Predominant IgG deposition was noted in 71 cases with prim...
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Introduction: IgA Nephropathy is the most common form of glomerulonephritis and the major cause of end-stage renal disease. Gross or microscopic hematuria is a common symptom of hematuria and occurs in less than 5% to 10% of patients with IGM with rapidly progressive glomerulonephritis. The aim of this study was to investigate the diagnostic biomarkers of this disease after biopsy. Methods: IgA...
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Anderson-Fabry disease is a rare inherited X-linked lysosomal storage disease caused by deficiency of the enzyme alpha-galactosidase A. Hereby we report a 39 year old male that presented with proteinuria and edema. Histopathologic, immunofluorescence and ultrastractural examination of renal tissue were in favor of Fabry disease in associate with IgA nephropathy. Fabry's disease associated ...
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ورودعنوان ژورنال:
- Clinical journal of the American Society of Nephrology : CJASN
دوره 12 4 شماره
صفحات -
تاریخ انتشار 2017